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Foffa I et al. – The authors reported a case of 64 year–old patient with BAV and a history of ankylosing spondylitis and systemic lupus erythematosus, and who developed ascending thoracic aortic aneurysm. The patient presented also the homozygosity for genetic variants of MMP9, ACE, MTHFR and PAI–1 genes. Gene–environmental interactions may represent an additional pathogenetic dimension in the still challenging management of the abnormalities of the aortic wall, including dilatation, aneurysm and dissection.

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