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Lymphotropic nanoparticle-enhanced magnetic resonance imaging identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy
Clinical Imaging, 06/26/09

Ross RW et al. - Twenty-six patients with prostate cancer status post-radical prostatectomy who were candidates for salvage radiation therapy underwent lymphotropic nanoparticle enhanced MRI using superparamagnetic nanoparticle ferumoxtran-10. LNMRI was well tolerated, with only two adverse events, both Grade 2. Six of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on size criteria.

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