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Four-year clinical update from the American Society of Breast Surgeons MammoSite brachytherapy trial
The American Journal of Surgery, 06/25/09

Nelson JC et al. – Study reports that the locoregional control, complications, and cosmetic outcomes from MammoSite partial breast irradiation (APBI) at the 4-year update are acceptable and similar to results seen with other forms of APBI.

Methods

A 4-year update on the efficacy, cosmetic results, and complications of MammoSite breast brachytherapy in pts enrolled in the American Society of Breast Surgeons registry trial is presented
1,449 breasts in 1,440 pts with early stage BCa undergoing breast-conserving therapy
Pts were treated with adjuvant APBI (34 Gy in 3.4-Gy fractions) delivered with the MammoSite device
Median follow-up period for the entire group was 36.1 months

Results

3-yr actuarial rate of ipsilateral breast tumor recurrence was 2.15%
3-yr actuarial rate of axillary recurrence was 0.36%
Complication rates were: infection, 9.5%; seroma, 26.8%, symptomatic seroma, 12.7%; and fat necrosis, 2.0%
Percentages of breasts with good or excellent cosmetic results were: 12 mo, 95%; 24 mo, 94%; 36 mo, 94%; and 48 mo, 91%

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Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers
Journal of Clinical Oncology, 10/29/09 Relevance Score: 97%

New-Onset Breast Tenderness After Initiation of Estrogen Plus Progestin Therapy and Breast Cancer Risk
Archives of Internal Medicine, 10/13/09 Relevance Score: 97%

Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: The UK MARIBS study
Breast Cancer Research, 11/17/09 Relevance Score: 96%

Breast-feeding the last born child and risk of ovarian cancer
Cancer Causes and Control, 11/16/09 Relevance Score: 96%

Novel breast tissue feature strongly associated with risk of breast cancer
Journal of Clinical Oncology, 10/08/09 Relevance Score: 96%