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See Latest ArticlesPediatric MDCT: Towards assessing the diagnostic influence of dose reduction on the detection of small lung nodules
Academic Radiology, 06/22/09
Li X et al. – Study reports that tube current (dose) has a weak effect on the detection accuracy of small lung nodules in pediatric multidetector array computed tomography (MDCT). The effect on detection accuracy of a 75% dose reduction was comparable to interobserver variability, suggesting a potential for dose reduction.
Methods- An evaluation of the effect of reduced tube current (dose) on lung nodule detection in pediatric MDCT
- Study included normal clinical chest MDCT images of 13 pts (aged 1-7 yrs) scanned at tube currents of 70 to 180 mA
- Calibrated noise addition software was used to simulate cases as they would have been acquired at 70 mA, 35 mA, and 17.5 mA
- Small lung nodules of 3-5 mm in diameter were inserted into the cases
- They were then randomized and rated independently by 3 experienced pediatric radiologists for nodule presence on a continuous scale ranging from 0-100
- The observer data were analyzed to assess the influence of dose on detection accuracy
- The areas under the ROC curves were 0.95, 0.91, and 0.92 at 70, 35, and 17.5 mA, respectively, with standard errors of 0.02 and interobserver variability of 0.02
- The Dorfman-Berbaum-Mets method and the Williams trend test yielded P values for the effect of dose of .09 and .05, respectively
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