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Improved selection of patients for hepatic surgery of colorectal liver metastases with 18F-FDG PET: a randomized study
The Journal of Nuclear Medicine, 06/15/09

Ruers TJM et al. - In a study to investigate whether the addition of 18F-FDG PET is beneficial and reduces the number of futile laparotomies in pts with colorectal liver metastases, it appears that the number of futile laparotomies was reduced from 45% to 28%; thus, the addition of 18F-FDG PET to the work-up for surgical resection of colorectal liver metastases prevents unnecessary surgery in 1 of 6 pts.

Methods

150 pts with colorectal liver metastases selected for surgical treatment by imaging with CT were randomly assigned to CT only (n=75) or CT plus 18F-FDG PET (n=75).
Pts were followed up for at least 3 yr.
Primary outcome measure was futile laparotomy, defined as any laparotomy that did not result in complete tumor treatment, that revealed benign disease, or that did not result in a disease-free survival period longer than 6 mo.

Results

Pt and tumor characteristics were similar for both groups.
Number of futile laparotomies was 34 (45%) in the control arm without 18F-FDG PET and 21 (28%) in the experimental arm with 18F-FDG PET; the relative risk reduction was 38%.

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