Radiology Medical News about hip fracture;local topological anyalsis of densitometer-generated scan images of proximal femur

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Local topological analysis of densitometer-generated scan images of the proximal femur for differentiation between patients with hip fracture and age-matched controls
Osteoporosis International, 08/12/08

Boehm HF et al. – Identification of patients with hip fracture by regional evaluation of density patterns varies with anatomical location within the proximal femur. In this study population, performance of the novel parameter was superior to densitometry.

Methods

Study to evaluate densitometer-generated scan images of the proximal femur with respect to topological properties of bone mineral distribution patterns
Ability for differentiation between post-menopausal women hip fracture and controls was also tested and to compare results with standard bone densitometry
Dual-energy X-ray absorptiometry (DXA) was used to measure the femoral BMD of 100 post-menopausal women
50 of these had a recent hip fracture
Local bone mineral distribution in the scanner-generated images was analyzed in the standard DXA-regions of interest
Performance of topological analysis and BMD was tested by receiver–operator characteristic and discriminant analysis

Results

Area under the curve (AUC) for correct differentiation between pts with and w/o fractures by BMD in the different ROIs ranged from 0.64 to 0.71
AUC of regional density-pattern analysis varied between 0.79 and 0.84
Between 71% and 84% of pts were correctly identified as fracture/non-fracture cases by regional topological analysis
Whereas BMD reached levels from 58% to 68%

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