M1 Susceptibility Vessel Sign on T2 as a Strong Predictor for No Early Recanalization After IV-t-PA in Acute Ischemic Stroke Kimura K et al. - In acute stroke patients treated with intravenous tissue plasminogen activator (t-PA), early recanalization of occluded arteries can improve the clinical outcome. The magnetic susceptibility effect of deoxygenated hemoglobin in red thrombi can present as hypointense signals on T2-weighted gradient echo imaging. The M1 SVS on T2 appears to be a strong predictor for no early recanalization after t-PA therapy. [more...]