Relationship of compartment-specific structural knee status at baseline with change in cartilage morphology: A prospective observational study using data from the osteoarthritis initiative
Eckstein F et al. – Data indicate that radiographic and MRI cartilage morphometry features suggestive of advanced disease appear to be associated with greater cartilage loss; may help for selecting pts with a higher likelihood of fast progression in studies that attempt to demonstrate the cartilage-preserving effect of DMARDs.Methods- An investigation of the:
- Relationship of cartilage loss with compartment-specific baseline radiographic findings and MRI cartilage morphometry features, and
- Identify which baseline features can be used for stratification of fast progressors
- An age and gender stratified subsample of OA initiative progression subcohort:
- 79 women; 77 men
- Mean age: 60.9+/-9.9 yrs
- BMI: 30.3+/-4.7 with symptomatic, radiographic OA in one knee
- Baseline fixed flexion radiographs were read centrally
- Adjudicated and cartilage morphometry was performed at baseline and at 1 yr f/u from coronal FLASH 3 Tesla MR images of the right knee
Results- Osteophyte status at baseline was not associated with medial cartilage loss
- Knees with medial joint space narrowing showed higher rates of change than those w/o, although not significant
- Higher cartilage loss both with and w/o adjusting for age, sex and BMI were displayed by:
- Knees with medial femoral subchondral bone sclerosis (radiography)
- Medial denuded subchondral bone areas (MRI), and
- Low cartilage thickness (MRI) at baseline
- Participants with denuded subchondral bone showed a standardized response mean of up to -0.64 vs -0.33 for the entire subcohort
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