Mammographic findings of partial breast irradiation
Kuzmiak CM et al. - In a trial to determine if pts who underwent partial-breast irradiation followed by segmental mastectomies had fewer mammographic changes on the first post-treatment mammogram than those who underwent segmental mastectomies followed by whole-breast irradiation, it appears that pts have a higher probability of having fewer post-treatment mammographic changes after partial-breast irradiation followed by segmental mastectomy than after breast conservation surgery followed by whole-breast irradiation. Methods- Subjects enrolled in a study of partial-breast irradiation therapy after segmental mastectomy (intraoperative radiation therapy) plus a random sample of pts who underwent segmental mastectomies followed by conventional whole-breast radiation therapy were identified through the institution's breast cancer database.
- A radiologist specializing in breast imaging reviewed and recorded each pt's pretreatment mammogram for breast density and tumor location and the first post-treatment mammogram, obtained within the first yr of treatment, for 3 common types of mammographic change seen after breast surgery and radiation treatment (breast edema, skin thickening, and surgical scarring), which when severe make it difficult to use mammography for continuing follow-up of the conserved breast.
- The extent of mammographic change was noted by the radiologist as minimal, moderate, or marked.
- Data were entered into a database, and statistical analysis was conducted using logistic regression models and ?2 tests.
- Effect of breast density on mammographic change was assessed.
Results- Severity of edema was lower with decreasing breast density.
- There was no apparent effect of breast density on the severity of skin thickening.
- Extent of surgical scarring decreased as breast density increased.
- Analysis of data from the cumulative logistic regression models demonstrated that even after controlling for breast density, pts who underwent whole-breast radiation therapy had significantly more edema, skin thickening, and surgical scarring than those who underwent intraoperative radiation therapy.
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