Top prostate Articles in Radiology

Zinc and prostatic cancer
Current Opinion in Clinical Nutrition & Metabolic Care, 10/16/2009

The prostate contains the highest concentration of zinc of all the soft tissues, but concentrations decrease significantly during prostate cancer. A growing body of experimental evidence supports the notion that high zinc levels are essential for prostate health and may limit prostate cancer ... in normal prostate epithelial cells by modulating DNA repair and damage response proteins, especially p53. In addition, recent findings support the role of zinc transporters as tumor suppressors in the prostate. More in–vivo studies on the effects of zinc on prostate functions are necessary to ... interaction between zinc and prostate function. In humans, sensitive and specific zinc biomarkers significantly impair the ability to design and interpret clinical studies and should be a priority area of research. [more...]

Routine evaluation of prostate size not as effective in cancer screening
EurekAlert, 11/11/2009

New Mayo Clinic research studied the association between prostate–specific antigen levels and prostate size and found that routine annual evaluation of prostate growth is not necessarily a predictor for the development of prostate cancer ... However the study suggests that if a man's PSA level is rising quickly, a prostate biopsy is reasonable to determine if he has prostate cancer. [more...]

Prostate specific antigen for early detection of prostate cancer: longitudinal study
British Medical Journal, 10/08/2009

Holmstrom B et al. – No single cut–off value for prostate specific antigen concentration attained likelihood ratios formally required for a screening test. Prostate specific antigen concentrations ... virtually ruled out a prostate cancer diagnosis during the follow–up. Additional biomarkers for early detection of prostate cancer are needed before population based screening for prostate cancer should be introduced. [more...]

Operator is an Independent Predictor of Detecting Prostate Cancer at Transrectal Ultrasound Guided Prostate Biopsy
The Journal of Urology, 11/23/2009

Lawrentschuk N et al. – Significant differences in prostate cancer detection exist among operators who perform transrectal ultrasound guided prostate biopsy even in the same setting. The ... prostate biopsies does not appear to influence the positive prostate cancer detection rate, nor could a learning curve be identified. Differences in prostate cancer detection among operators are likely related to unknown differences in expertise or technique. Further research is needed. [more...]

A prospective study of lifetime physical activity and prostate cancer incidence and mortality
British Journal of Cancer, 11/02/2009

Orsini N et al. – The results of this study suggest that not sitting for most of the time during work or occupational activity and walking or bicycling more than 30 min per day during adult life is associated with reduced incidence of prostate cancer. prostate cancer incidence (n=2735) and to December 2006 for its subtypes and for fatal (n=190) prostate cancer Results Observed an inverse association between lifetime (average of age 30 and 50 years, and baseline age) total PA levels and prostate cancer risk Observed an inverse association between average lifetime work or occupational activity and walking or bicycling duration and prostate cancer risk Compared with men who mostly sit during their main work or occupation, men who sit half of time experienced a 20% lower risk prostate cancer for every 30 min per day increment of lifetime walking or bicycling in range of 30 to 120 min per day [more...]

Exercise and Prostate Cancer Risk in a Cohort of Veterans Undergoing Prostate Needle Biopsy
The Journal of Urology, 10/19/2009

Antonelli JA et al. – These results provide the first evidence of an association between exercise and prostate cancer risk as well as grade at diagnosis in men scheduled to undergo prostate biopsy ... risk of prostate cancer and in men with cancer, lower grade disease. Further investigation using an objective measure of exercise in a larger sample size is required to confirm these findings. [more...]

Prostate Cancer Specific Mortality and Gleason 7 Disease Differences in Prostate Cancer Outcomes Between Cases With Gleason 4 + 3 and Gleason 3 + 4 Tumors in a Population Based Cohort
The Journal of Urology, 11/20/2009

Wright JL et al. – Gleason 7 prostate cancer shows heterogeneous behavior with Gleason 3 + 4 and 4 + 3 ... different prostate cancer specific mortality. These data provide important information for counseling patients with Gleason 7 prostate cancer on the natural history of the disease and may inform treatment decisions. [more...]

Serial Prostate Biopsies are Associated With an Increased Risk of Erectile Dysfunction in Men With Prostate Cancer on Active Surveillance
The Journal of Urology, 11/23/2009

Fujita K et al. – Serial prostate biopsies appear to have an adverse effect on erectile function in men with prostate cancer on active surveillance but do ... affect lower urinary tract symptoms. [more...]

Validation in a Multiple Urology Practice Cohort of the Prostate Cancer Prevention Trial Calculator for Predicting Prostate Cancer Detection
The Journal of Urology, 11/13/2009

Eyre SJ et al. – Differences between the Early Detection Research Network validation cohort and the Prostate Cancer Prevention Trial cohort underscore the ... setting. Our findings extend the applicability of the Prostate Cancer Prevention Trial calculator for measuring the risk of prostate cancer detection on biopsy to the routine American urology practice setting. [more...]

Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men
The Prostate, 11/02/2009

Zheng SL et al. – The study shows that multiple prostate cancer risk loci identified in European populations by GWAS are also associated with prostate cancer risk in Chinese men, a low–risk ... mostly clinically relevant cancers. Larger studies in Chinese and Asian populations are needed to confirm these findings and the role of these risk loci in prostate cancer etiology in Asian men. [more...]