Top prostate Articles in Radiology

Zinc and prostatic cancer
Current Opinion in Clinical Nutrition & Metabolic Care, 10/16/2009

The prostate contains the highest concentration of zinc of all the soft tissues, but concentrations decrease significantly during prostate cancer. A growing body of experimental evidence supports the notion that high zinc levels are essential for prostate health and may limit prostate cancer ... in normal prostate epithelial cells by modulating DNA repair and damage response proteins, especially p53. In addition, recent findings support the role of zinc transporters as tumor suppressors in the prostate. More in–vivo studies on the effects of zinc on prostate functions are necessary to ... interaction between zinc and prostate function. In humans, sensitive and specific zinc biomarkers significantly impair the ability to design and interpret clinical studies and should be a priority area of research. [more...]

Prostate specific antigen for early detection of prostate cancer: longitudinal study
British Medical Journal, 10/08/2009

Holmstrom B et al. – No single cut–off value for prostate specific antigen concentration attained likelihood ratios formally required for a screening test. Prostate specific antigen concentrations ... virtually ruled out a prostate cancer diagnosis during the follow–up. Additional biomarkers for early detection of prostate cancer are needed before population based screening for prostate cancer should be introduced. [more...]

A prospective study of lifetime physical activity and prostate cancer incidence and mortality
British Journal of Cancer, 11/02/2009

Orsini N et al. – The results of this study suggest that not sitting for most of the time during work or occupational activity and walking or bicycling more than 30 min per day during adult life is associated with reduced incidence of prostate cancer. prostate cancer incidence (n=2735) and to December 2006 for its subtypes and for fatal (n=190) prostate cancer Results Observed an inverse association between lifetime (average of age 30 and 50 years, and baseline age) total PA levels and prostate cancer risk Observed an inverse association between average lifetime work or occupational activity and walking or bicycling duration and prostate cancer risk Compared with men who mostly sit during their main work or occupation, men who sit half of time experienced a 20% lower risk prostate cancer for every 30 min per day increment of lifetime walking or bicycling in range of 30 to 120 min per day [more...]

Exercise and Prostate Cancer Risk in a Cohort of Veterans Undergoing Prostate Needle Biopsy
The Journal of Urology, 10/19/2009

Antonelli JA et al. – These results provide the first evidence of an association between exercise and prostate cancer risk as well as grade at diagnosis in men scheduled to undergo prostate biopsy ... risk of prostate cancer and in men with cancer, lower grade disease. Further investigation using an objective measure of exercise in a larger sample size is required to confirm these findings. [more...]

Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men
The Prostate, 11/02/2009

Zheng SL et al. – The study shows that multiple prostate cancer risk loci identified in European populations by GWAS are also associated with prostate cancer risk in Chinese men, a low–risk ... mostly clinically relevant cancers. Larger studies in Chinese and Asian populations are needed to confirm these findings and the role of these risk loci in prostate cancer etiology in Asian men. [more...]

Detection rate and factors predictive the presence of prostate cancer in patients undergoing ultrasonography-guided transperineal saturation biopsies of the prostate
BJU International, 11/06/2009

Novara G et al. – TRUS–guided transperineal saturation re–biopsy of the prostate using a 24–core scheme resulted in a ... who had had two or more previous biopsies. The total prostate volume was the only predictor of prostate cancer. [more...]

Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer
Cancer Immunology, Immunotherapy, 10/26/2009

Seliger B et al. – Results suggest that HLA class I APM component abnormalities are mainly due to regulatory mechanisms, play a role in the clinical course of prostate cancer and on the outcome of T cell-based immunotherapies prostate carcinoma, adjacent normal tissues, as well as in prostate carcinoma cell lines Results IFN-? inducible proteasome subunits LMP2 and LMP7, TAP1, TAP2, calnexin, calreticulin, ERp57, and tapasin are strongly expressed in the cytoplasm of normal prostate cells ... I heavy chain (HC) and ?2-microglobulin are expressed on the cell surface Most of APM components downregulated in substantial number of prostate cancers With exception of HLA class I HC, TAP2 and ERp57 not detectable in about 0.5% of tumor lesions, all other APM components not ... recurrence Prostate carcinoma cell lines also exhibit heterogeneous, but reduced constitutive APM component expression pattern associated with lack or reduced HLA class I surface antigens, which could be upregulated by IFN-&upsilon [more...]

Prostate Specific Antigen Best Practice Statement: 2009 Update
The Journal of Urology, 11/02/2009

Greene KL et al. – Although recently published trials show different results regarding the impact of prostate cancer screening on mortality, both suggest that prostate cancer screening leads to overdetection and overtreatment of ... the risks and benefits of prostate cancer screening before biopsy and the option of active surveillance in lieu of immediate treatment for certain men diagnosed with prostate cancer. [more...]

Could mining be protective against prostate cancer? A study and literature review
Occupational and Environmental Medicine, 10/21/2009

Girschik J et al. – After controlling for age, family history and military service in Vietnam, miners had a statistically significantly reduced risk of prostate cancer (AOR 0.35 95% CI 0.16–0.75). The ... studies examining mining and prostate found a reasonably consistent trend of a decreased risk of prostate cancer amongst miners. None of the published articles discussed their results regarding mining and prostate cancer in detail, and a biological mechanism to support these results has not ... relationship between mining and prostate cancer deserves further investigation. [more...]

Benefits and harms of widespread PSA test use still unclear
JAAPA, 10/21/2009

The prostate cancer screening controversy has become even more complex with the publication of two longawaited studies and the release of two conflicting screening guidelines...All the guidelines recommend that clinicians and patients engage in shared decision making around the topic of prostate ... patients of the risks and benefits of prostate cancer screening is essential, but it is also time–consuming. The CDC has published an easy–to–read booklet, Prostate Cancer Screening: A Decision Guide, available at www.cdc.gov/cancer/prostate/basic_info/screening.htm. There are ... in discussions leading to informed decision making regarding PSA testing. [more...]