The influence of chemotherapy on bone mineral density, quantitative ultrasonometry and bone turnover in pre-menopausal women with breast cancer
European Journal of Cancer, 10/23/2009
Hadji P et al. – Results confirm A/C’s deleterious influence on bone health in pre-menopausal women with BC and established QUS’s utility for monitoring bone effects. Methodsbone marker levels measured at baseline, 6 and 12months Correlations between parameters determined by Spearman’s rhoResults- All BC patients became amenorrhoeic after chemotherapy and remained so for duration of treatment
- BC patients had significant bone loss ... at all sites and significant increases in bone turnover
- Significant correlations between BMD, QUS and bone markers
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Bone sialoprotein, but not osteopontin, deficiency impairs the mineralization of regenerating bone during cortical defect healing
Bone, 10/08/2009
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Monfoulet L et al. – The data suggest that BSP, but not OPN, plays a role in primary bone formation and mineralization of newly formed bone during the process of ... cortical bone healing.
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Bone Diseases
MedLinePlus, 10/29/2009
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Your bones help you move, give you shape and support your body. They are living tissues that rebuild constantly throughout your life. During childhood and your teens, your body adds new bone faster than it removes old bone. After about age 20, you can lose bone faster than you make ... bone. To have strong bones when you are young, and to prevent bone loss when you are older, you need to get enough calcium, vitamin D and exercise.
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Treatment of Large Segmental Bone Defects with Reamer-Irrigator-Aspirator Bone Graft: Technique and Case Series
Orthopedic Clinics of North America, 11/24/2009
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McCall TA et al. – Treatment of large segmental defects using conventional autogenous iliac crest bone graft can be limited by volume of cancellous bone and donor site morbidity. The reamer ... of cancellous bone graft containing growth factors with potency equal to or greater than autograft material from the iliac crest. The purpose of this study was to evaluate the effectiveness of RIA–harvested autogenous bone graft for treating large segmental defects of long bones.
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Clinical Use of Resorbable Polymeric Membranes in the Treatment of Bone Defects
Orthopedic Clinics of North America, 11/25/2009
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Meinig RP – The reconstruction of large bone defects remains a clinically challenging condition. Although many treatment approaches exist, they all have limitations. Recently, bioresorbable polylactide membranes ... to bone defects, enhance bone healing by direct osteoconduction, exclusion of nonosseous tissues, and enhancing the osteogenic environment for autologous grafts. When combined with appropriate internal fixation and autologous bone graft, bioresorbable polylactide membranes allow for single&ndash ... reconstruction of large bone defects.
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Associations between leisure physical activity participation and cortical bone mass and geometry at the radius and tibia in a Canadian cohort of postmenopausal women
Bone, 11/20/2009
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Hamilton CJ et al. – No associations were observed between TAS and trabecular bone parameters. Leisure PA participation is positively associated with cortical bone mass and geometry as ... and torsional strength at weight–bearing and non–weight–bearing bone sites and may have the potential to modify bone strength and influence bone fragility in postmenopausal women.
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Transient muscle paralysis disrupts bone homeostasis by rapid degradation of bone morphology
Bone, 11/17/2009
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Poliachik SL et al. – The timing, magnitude, and morphology of the observed bone erosion induced by transient muscle paralysis were consistent with a rapid recruitment and prolific activation of ... context, understanding how brief paralysis of a single muscle group can precipitate such rapid and profound bone resorption in an adjacent bone is likely to provide new insight into how normal muscle function modulates bone homeostasis.
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Bone signaling pathways and treatment of osteoporosis
Expert Review of Endocrinology & Metabolism, 11/10/2009
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Gogakos AI et al. – Bone turnover is a continuous process regulated by the coupled activities of osteocytes, osteoclasts and osteoblasts that maintain bone mass and strength. Osteoclastic bone resorption is regulated by the RANKL ... osteoprotegerin/RANK pathway, while osteoblastic bone formation is controlled by canonical Wnt signaling. Antiresorptive bisphosphonates remain the mainstay of treatment but recombinant parathyroid hormone is increasingly being used as an anabolic agent. Nevertheless, these drugs are limited by ... are promising anabolics. The recent identification of adipocytes and duodenal enterochromaffin cells as novel regulators of bone mass represent exciting opportunities for future drug development.
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Periprosthetic Bone Remodeling Using a Triple-Taper Polished Cemented Stem in Total Hip Arthroplasty
Journal of Arthroplasty, 11/10/2009
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Buckland AJ et al. – There was a statistically significant decrease in bone mineral density in all Gruen zones, but was most marked in zones 1 and 7. Periprosthetic bone density was reduced ... the first 3 to 9 months, after which recovery of bone density occurred. Greater calcar bone loss was seen in women, patients with a low preoperative bone density, and patients with poor postoperative mobility. Age at surgery did not effect calcar bone loss.
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Fat and Bone in Children – Differential Effects of Obesity on Bone Size and Mass According to Fracture History
Journal of Bone and Mineral Research, 10/20/2009
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Dimitri P et al. – The data suggest that fat mass substantially inhibits bone accrual in children with prior fracture. These children may require targeted interventions to increase bone ... mass during adolescence to achieve optimum peak bone mass and reduce the risk of osteoporosis later in life.
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