Relationship between cervical cord 1H-magnetic resonance spectroscopy and clinoco-electromyographic profile in amyotrophic lateral sclerosis
Muscle & Nerve, 06/12/2012
Ikeda K et al. – The metabolite ratios were associated with disease progression and ongoing denervation in neck and hand muscles. C1–C3 cord H–magnetic resonance spectroscopy (1H–MRS) might reflect anterior horn cell damage causing neck/arm weakness and respiratory dysfunction in amyotrophic lateral sclerosis (ALS) patients.Methods
- C1-C3 cord 1H-magnetic resonance spectroscopy (1H-MRS) was performed in 19 patients with amyotrophic lateral sclerosis (ALS) and 20 controls.
- N-acetylaspartate (NAA), choline-containing compounds, creatine plus phosphocreatine (Cr) and myo-Inositol (m-Ins) were measured.
- ALS Functional Rating Scale-Revised (ALSFRS) and forced vital capacity (FVC) were assessed.
- The rates of decline were calculated at 6 months before and after 1H-MRS.
- NAA/Cr and NAA/m-Ins were decreased significantly, and m-Ins/Cr was increased significantly in ALS patients compared to controls.
- NAA/Cr and NAA/m-Ins were correlated with ALSFRS and FVC and inversely linked to the decline rates.
- NAA/Cr, NAA/m-Ins and m-Ins/Cr were altered markedly in 9 patients with denervation and neurogenic changes in both C2 paraspinal and upper limb muscles.