mdlinx mdlinx
Latest (58) Full Text Articles (617) Article Summary

Spotty calcification as a marker of accelerated progression of coronary atherosclerosis: insights from serial intravascular ultrasound Full Text
JACC - Journal of the American College of Cardiology,

Kataoka Y et al. – The presence of spotty calcification is associated with more extensive and diffuse coronary atherosclerosis and accelerated disease progression despite use of medical therapies.

Methods
  • A total of 1,347 stable patients with angiographic coronary artery disease underwent serial evaluation of atheroma burden with intravascular ultrasound imaging.
  • Patients with spotty calcification were identified based on the presence of lesions (1 to 4 mm in length) containing an arc of calcification of <90°.
  • Clinical characteristics and disease progression were compared between patients with spotty calcification (n = 922) and those with no calcification (n = 425).

Results
  • Patients with spotty calcification were older (age 56 years vs. 54 years; p = 0.001), more likely to be male (68% vs. 54%; p = 0.01), and have a history of diabetes mellitus (30% vs. 24%; p = 0.01) and myocardial infarction (28% vs. 20%; p = 0.004), and have lower on–treatment high–density lipoprotein cholesterol levels (48 ± 16 mg/dl vs. 51 ± 17 mg/dl; p = 0.001).
  • Patients with spotty calcification demonstrated a greater percent atheroma volume (PAV) (36.0 ± 7.6% vs. 29.0 ± 8.5%; p < 0.001) and total atheroma volume (174.6 ± 71.9 mm3 vs. 133.9 ± 64.9 mm3; p < 0.001).
  • On serial evaluation, spotty calcification was associated with greater progression of PAV (+0.43 ± 0.07% vs. +0.02 ± 0.11%; p = 0.002).
  • Although intensive low–density lipoprotein cholesterol and blood pressure lowering therapy slowed disease progression, these efficacies were attenuated in patients with spotty calcification.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access Full Text, PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Radiology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Radiology Articles

Last month's top read Top Articles of 2013

1 Ultrasonography/MRI Versus CT for diagnosing appendicitis Full Text Pediatrics, March 14, 2014    Free full text    Clinical Article

2 A three year prospective study of repeat head computed tomography in patients with traumatic brain injury Journal of the American College of Surgeons, March 13, 2014    Clinical Article

3 Diagnostic accuracy of digital breast tomosynthesis versus digital mammography for benign and malignant lesions in breasts: A meta-analysis European Radiology, February 13, 2014    Evidence Based Medicine    Review Article    Clinical Article

4 Comparison of [18 F]FDG PET/CT and MRI in the diagnosis of active osteomyelitis Skeletal Radiology, March 28, 2014    Clinical Article

5 The diagnostic accuracy and outcomes after coronary computed tomography angiography vs. conventional functional testing in patients with stable angina pectoris: A systematic review and meta-analysis European Heart Journal – Cardiovascular Imaging, March 27, 2014    Evidence Based Medicine    Review Article    Clinical Article

6 Effect of integrating 3D-mammography (digital breast tomosynthesis) with 2D-mammography on radiologists true-positive and false-positive detection in a population breast screening trial European Journal of Cancer, March 4, 2014    Clinical Article

7 MR versus MR arthrography in detection of supraspinatus tendon tears in patients without previous shoulder surgery Skeletal Radiology, December 20, 2013    Review Article

8 FDG PET is a robust tool for the diagnosis of spondylodiscitis: A meta-analysis of diagnostic data Clinical Nuclear Medicine , March 19, 2014    Evidence Based Medicine    Review Article    Clinical Article

9 Aggregate cost of mammography screening in the United States: Comparison of current practice and advocated guidelines Annals of Internal Medicine, February 4, 2014    Evidence Based Medicine    Clinical Article

10 Diffusion-weighted MRI compared to FDG PET/CT for assessment of early treatment response in lymphoma Acta Radiologica, March 17, 2014    Clinical Article

11 Comparative outcomes for three-dimensional conformal versus intensity-modulated radiation therapy for esophageal cancer Diseases of the Esophagus, March 21, 2014    Review Article

12 Coronary stent evaluation with coronary computed tomographic angiography: Comparison between low-osmolar, high-iodine concentration iomeprol-400 and iso-osmolar, lower-iodine concentration iodixanol-320 Journal of Cardiovascular Computed Tomography, March 12, 2014    Clinical Article

13 Effectiveness of fluorography versus cineangiography at reducing radiation exposure during diagnostic coronary angiography The American Journal of Cardiology, March 26, 2014    Clinical Article

14 Clitoral size and location in relation to sexual function using pelvic MRI The Journal of Sexual Medicine, March 3, 2014

15 Intensity-modulated radiation therapy leads to survival benefit only in patients with high-risk prostate cancer: A population-based study Annals of Oncology, March 4, 2014    Clinical Article

16 11C-Choline PET/CT as a guide to radiation treatment planning of lymph-node relapses in prostate cancer patients European Journal of Nuclear Medicine & Molecular Imaging, March 10, 2014    Clinical Article

17 Ionising radiation-free whole-body MRI versus 18F-fluorodeoxyglucose PET/CT scans for children and young adults with cancer: a prospective, non-randomised, single-centre study The Lancet Oncology, March 6, 2014    Clinical Article

18 The effective use of acai juice, blueberry juice and pineapple juice as negative contrast agents for magnetic resonance cholangiopancreatography in children Pediatric Radiology, February 28, 2014    Evidence Based Medicine    Clinical Article

19 Ultrasound-assisted thrombolysis for acute pulmonary embolism: a systematic review European Heart Journal, February 7, 2014    Evidence Based Medicine    Review Article

20 What effect does mammographic breast density have on lesion detection in digital mammography Clinical Radiology, March 14, 2014    Review Article

Indexed Journals in Radiology: Clinical Radiology, American Journal of Roengenology, Academic Radiologymore

Other Topics in Radiology

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close