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The use of bevacizumab among women with metastatic breast cancer
Cancer,
Clinical Article
Dawood S et al. – The survey results highlight the discord between the opinion of community oncologists and the Food and Drug Administration's (FDA's) recent decision to withdraw the indication of bevacizumab for metastatic breast cancer (MBC).
Methods- E-mails were sent out between September and November 2010 using a database of 3000 addresses maintained by the United Arab Emirates Cancer Congress.
- Individuals working for Roche or Genentech were excluded.
- The survey consisted of 22 questions that were divided into 3 parts addressing each participant's demographic profile, their opinion of the FDA's decision, and the typical use of bevacizumab in the community in the setting of MBC.
- A total of 564 participants were included in the final analysis, contributing to an 18.8% response rate.
- Of these participants, 14.6% were from the United States, 7.8% were from Canada, 31.1% were from Europe, 2.0% were from the United Arab Emirates, 11.1% were from Asia, and 33.3% were from other countries.
- The majority of participants believed progression-free survival to be a surrogate for overall survival, that cost played a role in the FDA's decision, and that the decision would adversely affect the future of newer drugs currently being investigated for MBC.
- The majority of participants indicated that they would use bevacizumab for triple receptor–negative MBC (46.5%), would use it in a first-line setting (44.7%), and would use it in combination with paclitaxel (51.9%).
