Klok FA et al. – Computed tomography pulmonary angiography (CTPA) is the imaging test of first choice. The presence or absence of pulmonary embolism can be determined with sufficient certainty without the need for additional imaging tests after a negative CTPA. Compression ultrasonography and ventilation–perfusion scintigraphy is reserved for patients with concomitant symptomatic deep vein thrombosis or a stringent contraindication for CTPA, respectively. Currently, magnetic resonance pulmonary angiography is not a suitable alternative for CTPA.