Boyd NF et al. – Variations in percent mammographic density (PMD) reflect variations in the amounts of collagen and number of epithelial and non–epithelial cells in the breast. Extensive PMD is associated with a marked increased risk of invasive breast cancer. The PMD phenotype is important in the context of breast cancer prevention because extensive PMD is common in the population, is strongly associated with risk of the disease, and unlike most breast cancer risk factors, can be changed. [more...]
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