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Ibuprofen Modulates NF-kB Activity but Not IL-8 Production in Cystic Fibrosis Respiratory Epithelial Cells
Respiration, 11/04/09

Dauletbaev N et al. – The present data do not support the hypothesis that ibuprofen down–regulates IL–8 production in response to TNF–alpha and IL–1–beta in CF respiratory epithelium. Suppression of NF–kB transcriptional activity does not discriminate between anti–inflammatory drugs with or without effects on IL–8 production. The authors speculate that NF–kB–independent mechanisms may be responsible for anti–IL–8 effects of dexamethasone.

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