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An immunological overview of allergen specific immunotherapy — subcutaneous and sublingual routes
Therapeutic Advances in Respiratory Disease, 11/06/09
Ozdemir C et al. – Due to the presence of high numbers of tolerogenic dendritic cell subsets in this region, programming of the immune system towards a regulatory state with unresponsiveness to specific allergens occurs. Induction of peripheral tolerance through the generation of regulatory T cells is the key event, with several functional modulations in the allergic immune response. With an increase in understanding of the mechanism of regulatory pathways, promising progresses in the field of allergen–specific immunotherapy will ensue and may provide new options for the treatment of allergic disorders.
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