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Methodological aspects of lung cancer clinical trials in the era of targeted agents
Lung Cancer, 11/03/09

Di Maio M et al. – The history of clinical trials with epidermal growth factor receptor inhibitors in advanced NSCLC is a good example of the uncertainty about predictive factors and selection criteria. Moreover, non–inferiority design has been used for several phase III trials comparing targeted agents with chemotherapy. In this review, recent aspects of clinical trials methodology in lung cancer are described, and examples of their application are discussed.

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Lung cancer: a biologically different disease in women?
Women's Health, 10/30/09 Relevance Score: 73%

Oestrogen plus progestin and lung cancer in postmenopausal women (Womens Health Initiative trial): a post-hoc analysis of a randomised controlled trial
The Lancet, 10/12/09 Relevance Score: 72%

Haplotype and Cell Proliferation Analyses of Candidate Lung Cancer Susceptibility Genes on Chromosome 15q24-25.1
Cancer Research, 10/06/09 Relevance Score: 71%

Noninvasive detection of lung cancer by analysis of exhaled breath
BMC Cancer, 10/09/09 Relevance Score: 70%

African American lung cancer patients may have different response to new cancer-fighting drugs
EurekAlert, 10/08/09 Relevance Score: 70%