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Resuscitation Promoting Factors Reveal an Occult Population of Tubercle Bacilli in Sputum
American Journal of Respiratory and Critical Care Medicine, 11/03/09
Mukamolova GV et al. – Smear–positive sputum samples are dominated by a population of Mtb cells that can only be grown in the presence of Rpfs. These intriguing proteins are therefore relevant to human infection. The Rpf–dependent population is invisible to conventional culture and is progressively enhanced in relative terms during chemotherapy, indicating a form of phenotypic resistance that may be significant for both chemotherapy and transmission.
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