Pulmonology Medical News about Asthma BCG Vaccine Vaccination Child

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. 2008 Exclusive Survey—Earnings: Good news for primary care income

3. Medicare pay-for-reporting effort draws fire from frustrated doctors

4. Debunking Myths in the US Healthcare System

5. EGFR inhibitors as first-line therapy in advanced non-small cell lung cancer

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Does BCG vaccination protect against the development of childhood asthma? A systematic review and meta-analysis of epidemiological studies
International Journal of Epidemiology, 10/14/09

El–Zein M et al. – These results strengthen the epidemiological evidence in support of the hypothesis that exposure to the BCG vaccine in early life prevents asthma, possibly through a modulation of the immune maturation process.

Methods

Eligible studies were identified using a search strategy that included a computerized literature search and a manual search of each article's reference list, up to June 2008.
A total of 23 studies were included (10 cohort, 5 case–control and 8 cross–sectional). Each study was summarized and rated for methodological quality.
Three indicators of BCG exposure were considered including BCG vaccination, tuberculin response and scar diameter.

Results

The pooled estimate of association for 23 studies reporting on any of the three indicators suggested a protective effect of BCG exposure on childhood asthma occurrence.
The studies were heterogeneous, especially when tuberculin response was considered.
Restriction to a subgroup of 16 studies that considered BCG vaccination indicated a protective effect with no evidence of heterogeneity.
The overall pooled OR using an FE model was 0.86. Exclusion of three studies with the lowest quality scores showed a similar association.

<< Previous
Angiogenic and Angiostatic Chemokines in Idiopathic Pulmonary...

Next >>
Prospective Evaluation of Right Ventricular Function and...

Management of fever in children: Summary of the Italian pediatric society guidelines
Clinical Therapeutics, 10/19/09 Relevance Score: 86%

Physical interventions and injection techniques for reducing injection pain during routine childhood immunizations: Systematic review of randomized controlled trials and quasi-randomized controlled trials
Clinical Therapeutics, 10/16/09 Relevance Score: 85%

One Dose of H1N1 Vaccine Immunogenic in High Percentage of Youth Ages 10 to 17. Younger Children Likely Will Need Two Doses
American Family Physician, 10/05/09 Relevance Score: 84%

Antituberculous vaccine development: a perspective for the endemic world
Expert Review of Vaccines, 11/04/09 Relevance Score: 83%

Bacille Calmette-Guérin vaccine-related disease in HIV-infected children: a systematic review
The International Journal of Tuberculosis and Lung Disease, 10/28/09 Relevance Score: 82%