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See Latest ArticlesLung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity
The Journal of Thoracic and Cardiovascular Surgery, 10/13/09
Blasberg JD et al. – The authors demonstrated divergent effects of osteopontin isoforms on non–small cell lung cancer angiogenesis and vascular endothelial growth factor secretion. OPNa overexpression was associated with increased bovine capillary endothelial tubule length and vascular endothelial growth factor secretion, whereas OPNc was associated with decreases in both. These findings may lead to therapeutic strategies for selective isoform inhibition in non–small cell lung cancer.
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