Pulmonology

Your Article Summary

See Latest Articles

miRNAs in lung cancer - Studying complex fingerprints in patients blood cells by microarray experiments
BMC Cancer, 10/14/09

Keller A et al. – Our findings support the idea that neoplasia may lead to a deregulation of miRNA expression in blood cells of cancer patients compared to blood cells of healthy individuals. Furthermore, we provide evidence that miRNA patterns can be used to detect human cancers from blood cells

• Synthesized 866 human miRNAs and miRNA star sequences as annotated in Sanger miRBase onto microarray
• Using fully automated Geniom Real Time Analyzer platform, we analyzed miRNA expression in 17 blood cell samples of patients with NSCLC and in 19 blood samples of healthy controls

• Using t-test, detected 27 miRNAs significantly deregulated in blood cells of lung cancer patients as compared to controls
• Some of miRNAs validated using qRT-PCR
• Using subset of 24 miRNAs, radial basis function Support Vector Machine allowed for discriminating between blood cell samples of tumor patients and controls with an accuracy of 95.4% , a specicity of 98.1% , and a sensitivity of 92.5%

Today in Lung/Thoracic Oncology...keeping you current

Receive free subspecialty "5-minute updates" via email

A Small Step Towards Personalized Medicine for Non-small Cell Lung Cancer
Discovery Medicine, 12/15/09

Usefulness of fluoro-2-deoxyglucose positron emission tomography for investigating unexplained rising carcinoembryonic antigen levels that occur during the postoperative surveillance of lung cancer patients
International Journal of Clinical Oncology, 12/15/09

Comparison of chemotherapy regimens for concurrent chemoradiotherapy in unresectable stage III non-small cell lung cancer
International Journal of Clinical Oncology, 12/15/09

 See all of Lung/Thoracic Oncology