Pulmonology

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Systematic Review: Safety and Efficacy of Extended-Duration Antiviral Chemoprophylaxis Against Pandemic and Seasonal Influenza
Annals of Internal Medicine, 10/06/09

Khazeni N et al. – This review of 7 trials assessing the efficacy and safety of extended–duration (>4 weeks) treatment with oseltamivir and zanamivir suggests that the drugs prevent symptomatic but not asymptomatic seasonal influenza. Extended–duration zanamivir and oseltamivir chemoprophylaxis seems to be highly efficacious for preventing symptomatic influenza among immunocompetent white and Japanese adults. Extended–duration oseltamivir is associated with increased nausea and vomiting. Safety and efficacy in several subpopulations that might receive extended–duration influenza chemoprophylaxis are unknown.

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A Randomized Trial of Nebulized 3% Hypertonic Saline With Epinephrine in the Treatment of Acute Bronchiolitis in the Emergency Department
Archives of Pediatrics and Adolescent Medicine, 11/23/09

An Umbrella Review: Corticosteroid Therapy for Adults with Acute Asthma
American Journal of Medicine, 10/27/09

Intravenous Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension
The Journal of Pediatrics, 10/19/09

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Management of H1N1 influenza virus respiratory syndrome
Minerva Anestesiologica, 11/10/09

Novel Influenza A(H1N1): Clinical Presentation, Diagnosis, and Management
Pediatric Emergency Care, 11/16/09

Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome
JAMA, 11/04/09

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