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Budesonide/formoterol effects on metalloproteolytic balance in TGF-beta-activated human lung fibroblasts
Respiratory Medicine, 10/13/09

Todorova L et al. – The results suggest that the budesonide/formoterol combination enhanced metalloproteolytic activity of human lung fibroblasts via a synergistic decrease of TIMP–1, and that this mechanism may be involved in the synergistic inhibition of the TGF–beta–1–induced PG production. This implies that budesonide/formoterol combination therapy can counteract excessive matrix production and thus pathological airway fibrotic remodeling in asthma.

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