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The effects of anti-asthma drugs on the phagocytic clearance of apoptotic eosinophils by A549 cells
Respiratory Medicine, 10/07/09

Wang J et al. – The present study showed that all of the investigated anti–asthmatic drugs including dexamethasone, aminophylline and terbutaline play an anti–inflammatory effect by decreasing the release of IL–6 and IL–8 induced by LPS. On the other hand, they may have a different effect on the phagocytosis of apoptotic eosinophils by A549 cells, i.e., dexamethasone promotes the uptake of apoptotic eosinophils while aminophylline and terbutaline inhibit the ingestion of apoptotic eosinophils. These results revealed a novel aspect of dexamethasone, aminophylline and terbutaline in the treatment of asthma.

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