Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. 2008 Exclusive Survey—Earnings: Good news for primary care income 3. Medicare pay-for-reporting effort draws fire from frustrated doctors 4. Debunking Myths in the US Healthcare System 5. EGFR inhibitors as first-line therapy in advanced non-small cell lung cancer
Your Article Summary
See Latest ArticlesHuman Rhinovirus Infection Upregulates MMP-9 Production in Airway Epithelial Cells via NF-kB
American Journal of Respiratory Cell and Molecular Biology, 09/30/09
Tacon C et al. – Electrophoretic mobility shift assays and supershift assays confirmed nuclear translocation and binding of p50/p65 NF–kB subunits to a MMP–9 specific NF–kB oligonucleotide. This increase in MMP–9 may be a mechanism by which rhinovirus infections contribute to airway inflammation and, potentially, to airway remodeling.
Richard Leigh, 10/01/09
| Human rhinovirus (HRV) infections are major risk factors for the development of asthma in young children and exacerbations in individuals with established asthma; however the mechanisms by which this occurs are currently unknown. This has led us to hypothesize that HRV infection of human bronchial epithelial (HBE) cells play a role in the development and continued progression of airway inflammation and possibly remodeling. We show that HRV infection, both in vivo and in vitro, disrupts the MMP-9:TIMP-1 ratio by increasing MMP-9 but not TIMP-1 expression. Using pharmacological inhibitors, promoter luciferase constructs, electrophoretic mobility shift assays and supershift assays, we also show that the transcription factor NF-?B is necessary for the increased expression of MMP-9 upon HRV infection. This study provides a possible mechanism by which human rhinovirus (HRV) infections may contribute to the development and continued progression of airway inflammation and remodeling. |
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Respiratory Viral RNA on Toys in Pediatric Office Waiting Rooms
The Pediatric Infectious Disease Journal, 11/16/09
Absence of inflammation and pneumonia during infection with non-pigmented Yersinia pestis reveals new role for the pgm locus in pathogenesis
Infection and Immunity, 10/30/09
Pattern of Antioxidant and DNA Repair Gene Expression in Normal Airway Epithelium Associated with Lung Cancer Diagnosis
Cancer Research, 11/17/09
Sponsor
Article Search
Sponsor