Pulmonology Medical News about Asthma

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Differential gene expression and cytokine production from neutrophils in asthma phenotypes
European Respiratory Journal , 10/01/09

Baines KJ et al. – Non–eosinophilic and eosinophilic asthma are associated with specific gene expression profiles, providing further evidence that these phenotypes of asthma involve different molecular mechanisms of disease pathogenesis at the systemic level. The mechanisms of non–eosinophilic asthma may involve enhancement of blood neutrophil chemotaxis and survival.

Exclusive Author Commentary
K.J. Baines, 10/05/09

Non-eosinophilic asthma represents an alternative asthma phenotype where patients have asthma symptoms and heightened airway responsiveness in the absence of significant airway eosinophilia. Non-eosinophilic asthma is associated with a poor response to inhaled corticosteroid treatment. We have demonstrated that there is a distinct gene expression profile in non-eosinophilic asthma that is different to eosinophilic asthma. Our results suggest that a mechanism of non-eosinophilic asthma is an enhancement of motility and survival of circulating neutrophils. These results have important implications for the recognition and treatment of non-eosinophilic asthma, and provide further validation that the subtypes of asthma are caused by very different molecular mechanisms. Future research should investigate treatment options that reduce neutrophilic airway inflammation and improve ways to recognise non-eosinophilic asthma leading to personalised approaches to the management of asthma.

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Clinical importance of identifying immunoglobulin E-mediated disease in patients with Asthma
Clinical Cornerstone, 10/01/09 Relevance Score: 96%

Bone mineral density and fractures in older men with chronic obstructive pulmonary disease or asthma
Osteoporosis International, 10/13/09 Relevance Score: 95%

The Saudi Initiative for asthma
Annals of Thoracic Medicine, 10/13/09 Relevance Score: 95%

Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study
Journal of Allergy and Clinical Immunology, 10/09/09 Relevance Score: 95%

Identification of Asthma Phenotypes using Cluster Analysis in the Severe Asthma Research Program
American Journal of Respiratory and Critical Care Medicine, 11/09/09 Relevance Score: 94%