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See Latest ArticlesPolymorphisms in telomere maintenance genes and risk of lung cancer
Cancer Epidemiology, Biomarkers & Prevention, 09/30/09
Choi JE et al. – Genetic variants in the TERT and TNKS1 genes contribute to genetic susceptibility to lung cancer.
Methods- We captured 35 polymorphisms in the genes and determined their frequencies in 27 healthy Koreans
- Ten haplotype-tagging polymorphisms were examined in a case-control study that consisted of 720 lung cancer patients and 720 healthy controls
- The TERT rs2735940 g.C > T and rs2736098 g.G > A, and TNKS1 rs6985140 g.A > G were significantly associated with the risk of lung cancer
- In the haplotype analysis, the TERT rs2735940T/rs2736098A haplotype (ht4) was associated with a significantly increased risk of lung cancer compared with the rs2735940C/rs2736098G haplotype
- When the TERT ht4 and TNKS1 rs6985140G as risk alleles, the risk of lung cancer increased in a dose-dependent manner as the number of risk alleles increased
- Subjects with two to four risk alleles were at a significantly increased risk of lung cancer compared with subjects with zero risk allele
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Expression and Significance of Nrf2 and Its Target Genes in Pulmonary Adenocarcinoma A549 Cells Resistant to Cisplatin
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Today in Lung/Thoracic Oncology...keeping you current
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Choroidal metastases from lung adenocarcinoma
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