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Effect of in vitro aspirin stimulation on basophils in patients with aspirin-exacerbated respiratory disease
Clinical and Experimental Allergy, 09/22/09

Celik GE et al. – Basophil responses to in vitro aspirin challenge are poor indicators of clinical sensitivity. Aspirin activates some basophils by means of mechanisms that differ from the classical IgE–mediated pathway. The study also shows that the use of 27 mmof aspirin (5 mg/mL) by previous investigators causes non–specific basophil activation, thereby eliminating its usefulness in a cell–based diagnostic test for AERD. Evaluation of in vitro basophil activation has low clinical value in identifying aspirin–induced respiratory reactions.

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