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Expression and its Clinical Significance of NOK, EGFR in NSCLC
Chinese Journal of Lung Cancer, 09/22/09
Zhang Z et al. – The NOK proteins are highly expressed in the NSCLC, and the expression rates of NOK proteins are correlated with the cancers’ histological grades and TNM stages, which may be concern with tumorgenesis and progression; the positive expression rate and intensity of NOK protein correlate well with the expression of EGFR protein in NSCLC, which the activation of NOK probably owe to EGFR activation, all that would provide evidence for further study on the effective mechanism of NOK in the tumorigenesis or tumor progression.
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