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See Latest ArticlesEUS-FNA in the preoperative staging of non-small cell lung cancer
Lung Cancer, 09/21/09
Talbebian M et al. – Routine use of EUS-FNA in unselected patients with NSCLC reduces the need for surgical staging procedures in nearly half of patients. Additional surgical staging in patients without nodal metastases at EUS-FNA reduces the false negative EUS-FNA findings considerably regardless of the location of the primary lung tumor.
Methods- 152 consecutive operable patients with proven or suspected NSCLC who underwent EUS-FNA were retrospectively analyzed. In the absence of mediastinal metastases, mediastinoscopy and/or thoracotomy with lymph node dissection was performed.
- The prevalence of mediastinal metastases was 49%
- Sensitivity, negative predictive value (NPV) and accuracy of EUS-FNA for N2/N3 disease were 74%, 73% and 85% respectively, whereas these values for the combined staging of EUS-FNA and mediastinoscopy were 92%, 85% and 95%
- Additional surgical staging in patients staged N0 at EUS-FNA reduces the false negative EUS-findings by 55%
- The NPV of EUS-FNA for left-sided tumors was 68%
- EUS-FNA prevented surgical staging procedures in 60 of 152 patients (39%)
- No major complications occurred during EUS-FNA
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