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See Latest ArticlesTwo-round coamplification at lower denaturation temperature-PCR (COLD-PCR)-based sanger sequencing identifies a novel spectrum of low-level mutations in lung adenocarcinoma
Human Mutation, 09/21/09
Li J et al. – The ability to identify and sequence low–level mutations in the absence of elaborate microdissection, via COLD–PCR–based Sanger sequencing, provides a platform for accurate mutation profiling in clinical specimens and the use of TP53 as a prognostic/predictive biomarker, evaluation of cancer risk, recurrence, and further understanding of cancer biology.
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