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See Latest ArticlesVEGF Drives Autocrine Epithelial Cell Proliferation and Survival in Chronic Rhinosinusitis with Nasal Polyposis
American Journal of Respiratory and Critical Care Medicine, 09/24/09
Lee HS et al. – The data demonstrate that VEGF is a novel biomarker for chronic rhinosinusitis with hyperplastic sinonasal polyposis that functions in an autocrine feed forward manner to promote nasal epithelial cell growth and inhibit apoptosis. These findings implicate a previously unrecognized and novel role of VEGF functioning through neuropilin–1 on non–neoplastic primary human airway epithelial cells, to amplify cell growth, contributing to exuberant hyperplastic polyposis.
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