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See Latest ArticlesSomatostatin receptor tissue distribution in lung neuroendocrine tumours: a clinicopathologic and immunohistochemical study of 218 ‘clinically aggressive’ cases
Annals of Oncology, 09/18/09
Righi L et al. – The immunohistochemical determination of SSTRs, with special reference to low-grade/intermediate-grade tumours, may assist the clinical approach with somatostatin analogue-based diagnostic and therapeutic procedures in clinically aggressive pulmonary NETs.
Methods- A series of 218 lung NETs [24 metastatic typical carcinoids (TCs), 73 atypical carcinoids (ACs), 60 LCNECs and 61 surgically resected small-cell lung carcinomas] were investigated for SSTR types 2A and 3 tissue distribution using immunohistochemistry, in correlation with clinicopathologic parameters, outcome, scintigraphy and treatment
- SSTRs were heterogeneously distributed with a significant progressive decrease from low- to high-grade forms
- SSTR type 2A was strikingly overexpressed in metastatic TCs as compared with ACs and clinically benign TCs
- SSTR tissue immunolocalization correlated with octreotide scintigraphy in 20 of 28 cases
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