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Balamayooran G et al. – This review highlights the current understanding of the role of these molecules in the lungs during bacterial infection and their therapeutic potential. The authors also discuss emerging data on cholesterol and ethanol as environmentally modifiable factors that may impact neutrophilmediated pulmonary innate host defense. Understanding the precise molecular mechanisms leading to neutrophil influx in the lungs during bacterial infection is critical for the development of more effective therapeutic and prophylactic strategies to control the excessive host response to infection.

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