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Fujinaga H et al. – Hyperoxia decreases growth and disrupts VEGF–NO signaling in human preterm ECFCs. VEGF treatment restores growth in hyperoxia by increasing NO production. And NO treatment also increases growth during hyperoxia. Exogenous VEGF or NO may protect preterm ECFCs from the adverse effects of hyperoxia and preservation of ECFC function may improve outcomes of preterm infants.


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