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See Latest ArticlesPhase III study of pemetrexed plus carboplatin compared with etoposide plus carboplatin in chemotherapy-naive patients with extensive-stage small-cell lung cancer
Journal of Clinical Oncology, 09/04/09
Socinski MA et al. – Pemetrexed-carboplatin is inferior for the treatment of ES-SCLC.
Methods- Chemotherapy-naive patients with ES-SCLC and an Eastern Cooperative Oncology Group performance status of 0 to 2 were randomly assigned to receive pemetrexed-carboplatin (pemetrexed 500 mg/m2 on day 1; carboplatin at area under the serum concentration-time curve [AUC] 5 on day 1) or etoposide-carboplatin (etoposide 100 mg/m2 on days 1 through 3; carboplatin AUC 5 on day 1) every 3 weeks for up to 6cycles
- Pemetrexed-carboplatin was inferior to etoposide-carboplatin for OS(median, 8.1 v 10.6 mos) and PFS (median, 3.8 v 5.4 mos).
- ORR were also significantly lower for pemetrexed-carboplatin (31% v 52%)
- Pemetrexed-carboplatin had lower grade 3 to 4 neutropenia, febrile neutropenia, and leukopenia than etoposide-carboplatin
- Grade 3 to 4 thrombocytopenia was comparable between arms and anemia was higher in the pemetrexed-carboplatin arm
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