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Soulsby N et al. – Aminoglycoside dosing regimens have changed since the last survey was carried out in 1999. There has been an increase in the use of once–daily dosing from 54 to 88% of units. The reporting of both ototoxicity and renal toxicity has also increased (from 27 to 75% and from 19 to 65%, respectively). Standardization of management protocols for antibiotic use and patient monitoring may help reduce the risk of cumulative toxicity to aminoglycosides in CF patients.

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