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Cigarette smoke extract-induced COX-2 expression via a PKC-alpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kB pathway and p300 in tracheal smooth muscle cells
Lung Cellular and Molecular Physiology, 09/01/09
Yang CM et al. – These results demonstrated that in HTSMCs, CSE–induced COX–2–dependent PGE2 generation was mediated through PKC–alpha/c–Src/EGFR, PDGFR/PI3K/Akt leading to the recruitment of p300 with NF–kB complex.
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