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See Latest ArticlesSignal transduction pathways linking the activation of alveolar macrophages with the recruitment of neutrophils to lungs in chronic obstructive pulmonary disease
Experimental Lung Research, 08/24/09
Murugan V et al. – These stimuli seem to activate mainly redox–sensitive transcription factors such as nuclear factor (NF)–kB and activator protein (AP)–1, both of which play a major role in the synthesis and secretion of chemotactic factors such as IL–8 and leukotriene B4 (LTB4). The pathways involved in the synthesis and secretion of other factors such as macrophage chemotactic protein–1 (MCP–1) and growth–related oncogene–alpha (Gro–alpha) have also been reviewed.
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