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Population Pharmacokinetics of Linezolid in Adults with Pulmonary Tuberculosis
Antimicrobial Agents and Chemotherapy, 09/03/09
McGee B et al. – Linezolid administered twice daily produced higher values for free drug area under the concentration–time curve (AUC)/MIC and time above MIC. Both regimens achieved free AUC/MIC ratios > 100. Median times above the MIC for free drug were 100% (twice daily) and 63% (once daily).
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