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See Latest ArticlesPrevalence and risk factors for pulmonary arterial hypertension in patients with lupus
Rheumatology, 08/13/09
Prabu A et al. – Study reports that the point prevalence of pulmonary arterial hypertension (PAH) was 4.2% in this cohort of patients with systemic lupus erythematosus (SLE); most of the PAH cases were of mild severity. The significant association of lupus anti coagulant (LAC) and presence of anti-phospholipid antibodies (APS) in PAH cases suggests that thrombosis may play an important role in PAH with SLE.
Methods- Study aims to estimate the point prevalence of PAH and identify risk factors for PAH in SLE pts
- 288 pts; resting transthoracic echocardiography was performed to:
- Estimate the pulmonary artery pressures, and
- Assess cardiac morphology and function
- PAH was defined as systolic pulmonary artery pressure (sPAP) >30 mmHg
- Potential risk factors assessed:
- presence of lung disease, respiratory muscle weakness,
- autoantibodies, smoking, RP and APS
- Of 288 pts, 283 pts were suitable for analysis
- 12 pts had PAH with sPAP >30 mmHg
- Range of sPAP in PAH pts was 31–59 mmHg
- 3 pts had sPAP >40 mmHg
- Only significant risk factor for PAH was LAC
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