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Tolker–Nielsen T et al. – The synergistic effect of the combined polyvalent anion–DNase treatment is most likely due to the capacity of polyvalent anions to dissociate DNA/F–actin bundles with bacteria and polysaccharides, leading to exposure of a greater number of DNase cleavage sites on the extracellular DNA. It is conceivable that treatment with soluble polyvalent anions as an adjunct to DNase treatment will represent an improvement in cystic fibrosis therapy.

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