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See Latest ArticlesActin Cytoskeleton Regulates Stretch-activated Ca2+ Influx in Human Pulmonary Microvascular Endothelial Cells
American Journal of Respiratory Cell and Molecular Biology, 08/05/09
Ito S et al. – Mechanical stretch activates Ca2+ influx via stretch–activated channels different from other Ca2+ influx pathways such as receptor– and store–operated Ca2+ entries in HPMVECs that is tightly regulated by the actin cytoskeleton. These results suggest that abnormal Ca2+ homeostasis due to excessive mechanical stretch during mechanical ventilation may play a role in ALI/ARDS progression.
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