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Caprini JA – Intermittent pneumatic compression in conjunction with currently available parenteral anticoagulants has shown the greatest efficacy in very–high–risk surgical patients. The new oral anticoagulants have similar efficacy and safety profiles as existing parenteral anticoagulants and allow easy and cost–effective outpatient administration without the need for monitoring. Since it has been shown that most venous thromboembolism events occur following hospital discharge, these new anticoagulants may result in very significant reduction in the overall incidence of venous thromboembolism events.

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