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Adamali H et al. – Treatment algorithms have now become more complex, with therapeutic options defined by pulmonary artery vasoreactivity, functional class, and response to treatment. Combination therapies are increasingly considered as clinical trials demonstrating the efficacy of this approach are emerging. Monitoring and measuring the response to treatment in clinical trials and clinical practice are evolving from the historical dependence on functional class and 6–minute walk test to include estimates of the delay in the time to clinical worsening and the response of emerging biomarkers. KEYWORDS


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