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See Latest ArticlesDysfunctional Cystic Fibrosis Transmembrane Conductance Regulator Inhibits Phagocytosis of Apoptotic Cells with Pro-inflammatory Consequences
Lung Cellular and Molecular Physiology, 07/27/09
Vandivier RW et al. – Ineffective efferocytosis in CFTR–deficient cells appears to have pro–inflammatory consequences, because apoptotic cells enhance IL–8 release by these cells, but not by wild–type controls. Therefore, in cystic fibrosis, dysregulated efferocytosis may lead to accumulation of apoptotic cells, impaired regulation of the inflammatory response, and ultimately may suggest a new therapeutic target.
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