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Etiology, Diagnosis, and Pharmacologic Treatment of Pediatric Pulmonary Hypertension
Pediatric Drugs, 07/27/09

Tulloh R – Treatment can start with oxygen at home at night or even during the day. Next is the use of oral phosphodiesterase inhibitors, mostly type V, such as sildenafil, which enhance endogenous nitric oxide. More potent are the endothelin receptor antagonists and the most potent are the prostanoids, especially epoprostenol, which is given by constant intravenous infusion. In addition to interventional catheterization with atrial septostomy, these agents have improved the prognostic outlook.

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