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See Latest ArticlesPredicting warfarin maintenance dose in patients with venous thromboembolism based on the response to a standardized warfarin initiation nomogram
Journal of Thrombosis and Haemostasis, 07/28/09
Lazo–langner A et al. – Maintenance warfarin dose can be accurately predicted using individual response to a standard warfarin initiation nomogram without the need for costly genetic testing.
Michael J. Kovacs, 08/05/09
| In this paper we present a mathematical model to predict warfarin maintenance dose based on the response to a standardized warfarin initiation nomogram. This approach takes advantage of using early INR responses and other clinical data to determine warfarin requirements. Using a standard dosing schedule for all patients is basically a way to 'challenge' the genetic makeup of individuals and results in a dose forecasting strategy similar in effectiveness to strategies including genetic information on vitamin K epoxide reductase and cytochrome P genes. It has the advantage that it does not need genetic testing, thus avoiding the inherent costs, and that it can be easily implemented using widely available commercial or open source software. This model can be used in conjunction with a previously validated warfarin initiation nomogram and it could help to improve the care of anticoagulated patients. A Lazo-Langner, MJ Kovacs |
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